IL12RB1 anticorps

N° du produit ABIN2689091

Cet anticorps Souris Monoclonal détecte spécifiquement IL12RB1 dans FACS. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour IL12RB1 anticorps (ABIN2689091)

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL12RB1 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 2-4E6

Détail du produit anti-IL12RB1 anticorps

Marque: BD Pharmingen™

Attributs du produit: Reacts with IL-12Rβ1 subunit, one of two subunits of the IL-12Rβ. IL-12R, expressed mainly on T cells or NK cells, is a member of the hemopoietin receptor superfamily and is related to gp130, granulocyte-colony stimulating factor (G-CSF) receptor and leukemia inhibitory factor (LIF). Reports indicate that together, subunits IL-12Rβ1 and IL-12Rβ2 bind IL-12 with high affinity. IL-12 is an immunomodulatory cytokine produced mainly by antigen-presenting cells (APC) and plays a role in promoting Th1-type responses and cell-mediated immunity. It stimulates proliferation of T cells and NK cells, enhances lytic activity of lymphokine-activated killer (LAK) cells and CTL. Profile of IL-12Rβ1 expressed on peripheral blood lymphocytes analyzed on a FACScan .

BD Pharmingen™ Purified Mouse Anti-Human CD212 - Purified - Clone 2.4E6 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-IL12RB1 (ABIN2689091)

Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).

Wu, Warrier, Carvajal, Chua, Minetti, Chizzonite, Mongini, Stern, Gubler, Presky, Gately: "Biological function and distribution of human interleukin-12 receptor beta chain." dans: European journal of immunology, Vol. 26, Issue 2, pp. 345-50, (1996) (PubMed).

Détails sur IL12RB1

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Autre désignation: CD212

Sujet: Synonyms: IL-12 receptor β1 subunit

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation